Corrigendum: Construction of a doramectin producer mutant from an avermectin-overproducing industrial strain of Streptomyces avermitilis
نویسندگان
چکیده
منابع مشابه
Construction of a single component producer from the wild type avermectin producer Streptomyces avermitilis.
Most microbial secondary metabolites are producec as complexes of closely related compoundsby theii producing organisms. The avermectins1*, milbemycins2 and nemadectins3~5) are typical examples produced ii such a manner. The milbemyciif complex is known t( consist of more than twenty components6 ~ 8), however only a few are commercial products. A rationale for thii phenomenon may be related to ...
متن کاملProduction and Screening of High Yield Avermectin B1b Mutant of Streptomyces avermitilis 41445 Through Mutagenesis
BACKGROUND Secondary metabolite production from wild strains is very low for economical purpose therefore certain strain improvement strategies are required to achieve hundred times greater yield of metabolites. Most important strain improvement techniques include physical and chemical mutagenesis. Broad spectrum mutagenesis through UV irradiation is the most important and convenient physical m...
متن کاملEngineered biosynthesis of milbemycins in the avermectin high-producing strain Streptomyces avermitilis
BACKGROUND Milbemycins, produced from Streptomyces hygroscopicus subsp. aureolacrimosus and Streptomyces bingchenggensis, are 16-membered macrolides that share structural similarity with avermectin produced from Streptomyces avermitilis. Milbemycins possess strong acaricidal, insecticidal, and anthelmintic activities but low toxicity. Due to the high commercial value of the milbemycins and incr...
متن کاملproduction and screening of high yield avermectin b1b mutant of streptomyces avermitilis 41445 through mutagenesis
conclusions: the hereditary stability analysis of the uv mentioning 45 minutes revealed the uv exposure time for mutants and 3 represented the colony taken from the plate irradiated for 45 minutes mutant showed that the production of avermectin b1b remained constant and no reverse mutation occurred after 15 generations. results: avermectin b1b-hyper-producing mutant, produced using these three ...
متن کاملInnovative approach for improvement of an antibiotic-overproducing industrial strain of Streptomyces albus.
Working with a Streptomyces albus strain that had previously been bred to produce industrial amounts (10 mg/ml) of salinomycin, we demonstrated the efficacy of introducing drug resistance-producing mutations for further strain improvement. Mutants with enhanced salinomycin production were detected at a high incidence (7 to 12%) among spontaneous isolates resistant to streptomycin (Str(r)), gent...
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ژورنال
عنوان ژورنال: Canadian Journal of Microbiology
سال: 2010
ISSN: 0008-4166,1480-3275
DOI: 10.1139/w09-904